The Darien Chest.

Yup, now you've seen it; the Darien Chest.
The complex locking system repaired recently, now sitting in Edinburgh, where it originally sailed from.
If it sailed with gold, I would have understood the locks, but as far as I can see, the ships sailed with seeds, trade goods, and totally stupid cargo.
Mirrors, and trinkets for the Mosquito Indians.
Turnip and leek seed for the farmers... (they were obviously going to ignore the copious indigenous fruits and veg, and going for a 'kale' mixture)
Hundreds of pounds of wigs.... YES, you heard me; WIGS.
A gold smelter..... to melt all that traded or stolen Spanish gold.
And a coin maker.... oh boy.... if only they knew then what we know now....

They would have taken..... more Doctors, more nurses, more dysentry tablets, MUCH more laudnum and opiate derivatives.
They would have taken more guns, pistols, knives, bayonets, and all other killing devices.
OR, the best thing of all, someone could have took the keys to the ships..... it would have saved 3000 lives, and a linking-at-the-hip with England.